MAML3 (clone MAML3/1303), anti-human
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SKU
AC-AH13458
Catalog Number: AC-AH13458
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: MAML3/1303
Applications: IHC-P, IF, FC
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: MAML3/1303
Applications: IHC-P, IF, FC
Datasheet
Request Information
Background:
MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4.This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jκ; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.
Other Names:
CAGH3; ERDA3; GDN; MAML3; Mastermind-like protein 3; TNRC3
Antigen Type:
Recombinant protein
Gene Name: MAML3 (HGNC:16272)
Gene ID: 55534
Primary Accession: Q96JK9
Other Accession: 586165
MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4.This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jκ; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.
Other Names:
CAGH3; ERDA3; GDN; MAML3; Mastermind-like protein 3; TNRC3
Antigen Type:
Recombinant protein
Gene Name: MAML3 (HGNC:16272)
Gene ID: 55534
Primary Accession: Q96JK9
Other Accession: 586165
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