MANF polyclonal, anti-human
€388.00
In stock
SKU
BS8641
Background:
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.
Alternative Name:
Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET, MANF, ARMET, ARP
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: MANF polyclonal antibody detects endogenous levels of MANF protein.
Immunogen:
Recombinant full length Human MANF.
MW: ~ 21kDa
Swis Prot.: P55145
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.
Alternative Name:
Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET, MANF, ARMET, ARP
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: MANF polyclonal antibody detects endogenous levels of MANF protein.
Immunogen:
Recombinant full length Human MANF.
MW: ~ 21kDa
Swis Prot.: P55145
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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