Mannan-binding Lectin (clone 1E2), anti-human
€1,171.00
In stock
SKU
250354
Protein Family: Glycan Binding Proteins
Pathway and Disease: Immune System
Description:
Mannan-binding lectin (MBL), also called mannose-binding lectin or protein, belongs to the C-type family of collectins, showing calcium-dependent binding to certain sugars. It consists of oligomers of triple-chain subunits and its binding and complement activating activities depend on its normal oligomerization. On binding to mannan-like microbial surface carbohydrates, MBL activates the complement system by means of its own lectin pathway, depending on the MBL-associated serine proteases (MASPs). Because of the presence of different structural and promoter alleles in the population, 12% or more of the population have low concentrations (<50ng/mL) of normally oligomerized, functional MBL in plasma or serum. This antibody is specific for MBL from human serum or plasma.
Alternate Names: Mannose-binding protein C, MBP-C, MBP1, Mannose-binding lectin, mannan-binding protein, MBL2, MBL
Application Notes: Product Cat. No. 250354 reacts strongly in ELISA with MBL coated directly onto the microtiter well. Product Cat. No. 250354 reacts in western blot with human MBL in both its oligomerized state and as single protein chain of 26 kDa. Product Cat. No. 250354 can be used to measure MBL in plasma or serum but is not specific for oligomerized MBL. E: 1:40,000; WB: 1:2,000
Accession No.: P11226
Antigen: MBL purified from human donor plasma and adsorbed onto aluminum hydroxide.
Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Immune System
Description:
Mannan-binding lectin (MBL), also called mannose-binding lectin or protein, belongs to the C-type family of collectins, showing calcium-dependent binding to certain sugars. It consists of oligomers of triple-chain subunits and its binding and complement activating activities depend on its normal oligomerization. On binding to mannan-like microbial surface carbohydrates, MBL activates the complement system by means of its own lectin pathway, depending on the MBL-associated serine proteases (MASPs). Because of the presence of different structural and promoter alleles in the population, 12% or more of the population have low concentrations (<50ng/mL) of normally oligomerized, functional MBL in plasma or serum. This antibody is specific for MBL from human serum or plasma.
Alternate Names: Mannose-binding protein C, MBP-C, MBP1, Mannose-binding lectin, mannan-binding protein, MBL2, MBL
Application Notes: Product Cat. No. 250354 reacts strongly in ELISA with MBL coated directly onto the microtiter well. Product Cat. No. 250354 reacts in western blot with human MBL in both its oligomerized state and as single protein chain of 26 kDa. Product Cat. No. 250354 can be used to measure MBL in plasma or serum but is not specific for oligomerized MBL. E: 1:40,000; WB: 1:2,000
Accession No.: P11226
Antigen: MBL purified from human donor plasma and adsorbed onto aluminum hydroxide.
Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
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