Mannan-binding Lectin Horse (clone 15C5), anti-human, horse, pig
€1,070.00
In stock
SKU
250356
Protein Family: Glycan Binding Proteins
Pathway and Disease: Immune System
Description:
Mannan-binding lectin (MBL), also called mannose-binding lectin or protein, belongs to the C-type family of collectins, showing calcium-dependent binding to certain sugars. It consists of oligomers of triple-chain subunits and its binding and complement activating activities depend on its normal oligomerization. On binding to mannan-like microbial surface carbohydrates, MBL activates the complement system by means of its own lectin pathway, depending on the MBL-associated serine proteases (MASPs). Because of the presence of different structural and promoter alleles in the population, 12% or more of the population have low concentrations (<50ng/mL) of normally oligomerized, functional MBL in plasma or serum. This antibody is specific for human MBL from plasma or serum, but cross-reacts strongly with MBL from horse and swine.
Alternate Names: Mannose-binding protein C, MBP-C, MBP1, Mannose-binding lectin, mannan-binding protein, MBL2, MBL
Application Notes: Product Cat. No. 250356 reacts strongly with human, horse and swine serum in ELISA when immobilized on mannan-coated microplate. A weaker reaction is seen when Product Cat. No. 250356 is used as a detection antibody for human MBL coated directly onto the microtiter plate. E: 1:250; WB: 1:100
Accession No.: P11226
Antigen: MBL purified from human donor plasma and adsorbed onto aluminum hydroxide
Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Immune System
Description:
Mannan-binding lectin (MBL), also called mannose-binding lectin or protein, belongs to the C-type family of collectins, showing calcium-dependent binding to certain sugars. It consists of oligomers of triple-chain subunits and its binding and complement activating activities depend on its normal oligomerization. On binding to mannan-like microbial surface carbohydrates, MBL activates the complement system by means of its own lectin pathway, depending on the MBL-associated serine proteases (MASPs). Because of the presence of different structural and promoter alleles in the population, 12% or more of the population have low concentrations (<50ng/mL) of normally oligomerized, functional MBL in plasma or serum. This antibody is specific for human MBL from plasma or serum, but cross-reacts strongly with MBL from horse and swine.
Alternate Names: Mannose-binding protein C, MBP-C, MBP1, Mannose-binding lectin, mannan-binding protein, MBL2, MBL
Application Notes: Product Cat. No. 250356 reacts strongly with human, horse and swine serum in ELISA when immobilized on mannan-coated microplate. A weaker reaction is seen when Product Cat. No. 250356 is used as a detection antibody for human MBL coated directly onto the microtiter plate. E: 1:250; WB: 1:100
Accession No.: P11226
Antigen: MBL purified from human donor plasma and adsorbed onto aluminum hydroxide
Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
| Is Featured? | No |
|---|
Write Your Own Review