MAP2K4 (clone 2D10D8,4G11B2,2D10C4,2D10C3), anti-human
€421.00
In stock
SKU
252676
Protein Family: Enzymes, Protein Kinases
Pathway and Disease: Signal Transduction
Description:
MAP2K4 (Mitogen-activated protein kinase kinase 4) is a 399-amino acid protein (~45 kDa), belongs to the family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. MEK-4 (also called MEK4/MKK4) activates both p38 and JNK MAP kinases MKK4 is a central mediator in the stress activated protein kinase signaling pathway that responds to a number of cellular and environmental stressors. By phosphorylating MAP kinases such as JNK, MKK4 can ultimately transmit stress signals to nuclear transcription factors that mediate various processes including proliferation, apoptosis, and differentiation. Its distinct biological functions have been identified for MKK4 including a role in development, hepatogenesis and metastasis suppression.
Alternate Names: Dual specificity mitogen-activated protein kinase kinase 4, MAP kinase kinase 4, MAPKK 4, JNK-activating kinase 1, MAPK/ERK kinase 4, MEK 4, SAPK/ERK kinase 1, SEK1, Stress-activated protein kinase kinase 1, SAPK kinase 1, SAPKK-1, SAPKK1, c-Jun N-terminal kinase kinase 1, JNKK, JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1, MAP2K4
Application Notes: IHC: 1:200-1:1000
Accession No.: P45985
Antigen: Purified recombinant fragment of MAP2K4 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Signal Transduction
Description:
MAP2K4 (Mitogen-activated protein kinase kinase 4) is a 399-amino acid protein (~45 kDa), belongs to the family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. MEK-4 (also called MEK4/MKK4) activates both p38 and JNK MAP kinases MKK4 is a central mediator in the stress activated protein kinase signaling pathway that responds to a number of cellular and environmental stressors. By phosphorylating MAP kinases such as JNK, MKK4 can ultimately transmit stress signals to nuclear transcription factors that mediate various processes including proliferation, apoptosis, and differentiation. Its distinct biological functions have been identified for MKK4 including a role in development, hepatogenesis and metastasis suppression.
Alternate Names: Dual specificity mitogen-activated protein kinase kinase 4, MAP kinase kinase 4, MAPKK 4, JNK-activating kinase 1, MAPK/ERK kinase 4, MEK 4, SAPK/ERK kinase 1, SEK1, Stress-activated protein kinase kinase 1, SAPK kinase 1, SAPKK-1, SAPKK1, c-Jun N-terminal kinase kinase 1, JNKK, JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1, MAP2K4
Application Notes: IHC: 1:200-1:1000
Accession No.: P45985
Antigen: Purified recombinant fragment of MAP2K4 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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