MAP2K5 (clone 5H11B10), anti-human

Background:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.

Research Area: Cancer, Cardiovascular, Signal transduction

Synonyms: MEK5, MAPKK5, PRKMK5, HsT17454

Immunogen: Purified recombinant fragment of human MAP2K5 (AA: 63-180) expressed in E. Coli.

Formulation: Purified antibody in PBS with 0.05% sodium azide.

Storage:
4°C|-20°C for long term storage