MAP3K11 Polyclonal Antibody

Background:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.

Research Area: Cancer, Signal transduction

Synonyms:
2610017K16Rik, EC 2.7.11.25, M3K11, Map3k11, MEKK11, MGC17114, Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Mixed lineage protein kinase 3, Mlk-3, Mlk3, Protein tyrosine kinase PTK1, PTK1, RHOE, SH3 domain containing proline rich kinase, SPRK, Src-homology 3 domain-containing proline-rich kinase

Immunogen: Synthetic peptide of human MAP3K11

Swissprot: Q16584
Gene Accession: NP_002410

Calculated MW: 93 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-15068/sc-536/sc-13072