MAP3K12 Polyclonal Antibody

Background:
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.

Research Area: Signal Transduction

Synonyms:
Dlk, Dual leucine zipper bearing kinase, Dual leucine zipper kinase DLK, Leucine-zipper protein kinase, M3K12, Map3k12, MAPK-upstream kinase, MEKK12, Mitogen-activated protein kinase kinase kinase 12, Mixed lineage kinase, MUK, Protein kinase MUK, ZPK, ZPKP1

Immunogen: Recombinant protein of human MAP3K12

Swissprot: Q12852
Gene Accession: BC050050

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.2 mg/mL
Dilution: IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-8125