MAP3K5 polyclonal(T842), anti-human
€0.00
In stock
SKU
AC-AP7911g
Catalog Number: AC-AP7911g
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB12839
Applications: WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB12839
Applications: WB, IHC-P
Datasheet
Request Information
Background:
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
Other Names:
Mitogen-activated protein kinase kinase kinase 5, Apoptosis signal-regulating kinase 1, ASK-1, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5, MAP3K5, ASK1, MAPKKK5, MEKK5
Target/Specificity:
This MAP3K5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 821-849 amino acids from human MAP3K5.
Antigen Region:
821-849
Antigen Type: Synthetic Peptide
Gene Name: MAP3K5
Gene ID: 4217
Primary Accession: Q99683
NCBI Accession: NP_005914.1
Other Accession: Q9WTR2; O95382; O35099; A2AQW0; Q6ZN16; Q21029
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
Other Names:
Mitogen-activated protein kinase kinase kinase 5, Apoptosis signal-regulating kinase 1, ASK-1, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5, MAP3K5, ASK1, MAPKKK5, MEKK5
Target/Specificity:
This MAP3K5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 821-849 amino acids from human MAP3K5.
Antigen Region:
821-849
Antigen Type: Synthetic Peptide
Gene Name: MAP3K5
Gene ID: 4217
Primary Accession: Q99683
NCBI Accession: NP_005914.1
Other Accession: Q9WTR2; O95382; O35099; A2AQW0; Q6ZN16; Q21029
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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