MAP3K7 (phospho-S412) polyclonal, anti-human

Background:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Synonyms: CSCF, FMD2, MEKK7, TAK1, TGF1a

Cellular Location: Cell membrane Cytoplasm Cytoplasmic side Peripheral membrane protein

Immunogen:
A phospho specific peptide corresponding to residues surrounding S412 of human MAP3K7

Gene Symbol: Phospho-MAP3K7-S412

Gene ID: 6885

Swiss prot: O43318

Calculated MW: 67kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.