MAP3K7 Polyclonal Antibody

Background:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Research Area: Cancer, Cardiovascular, Immunology, Signal Transduction

Synonyms:
CSCF, FMD2, MEKK7, TAK1, TGF1a, MAP3K7

Immunogen: Recombinant fusion protein of human MAP3K7 (NP_003179.1).

Swissprot: O43318
Gene ID: 6885

Calculated MW: 53 kDa/56 kDa/64 kDa/67 kDa
Observed MW: 75 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.