MAP4K4 (clone 4H9E7), anti-human

Protein Family: Enzymes, Protein Kinases

Pathway and Disease: Signal Transduction

Description:
MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4) is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway.

Alternate Names: Mitogen-activated protein kinase kinase kinase kinase 4, HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, Nck-interacting kinase HGK, KIAA0687, NIK MAP4K4

Application Notes: WB: 1:500-1:2000

Accession No.: O95819

Antigen: Purified recombinant fragment of MAP4K4(aa400-500) expressed in E. coli.

Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.