MAPE Antibody (C-term) Blocking Peptide

Background:
MAPE is an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, its gene is also expressed in acute leukemias.

Other Names:
Melanoma antigen preferentially expressed in tumors, Opa-interacting protein 4, OIP-4, Preferentially expressed antigen of melanoma, PRAME, MAPE, OIP4

Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6720b was selected from the C-term region of human MAPE. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Gene Name: PRAME {ECO:0000303|PubMed:9047241, ECO:0000312|HGNC:HGNC:9336}

Gene ID: 23532
Primary Accession: P78395
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.