MAPK1 (activat) (clone IL-13), anti-human, mouse, rat, O

Protein Family: Enzymes, Protein Kinases

Pathway and Disease: Signal Transduction, Cell Motility, Cell Communication, Immune System, Endocrine System, Nervous and Sensory Systems, Development and Behavior, Cancers, Metabolic Disorders, Infectious Diseases

Description:
Mitogen-activated protein kinase 1 (MAP kinase 1) is involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. MAP kinase 1 acts as a transcriptional repressor. MAP kinase 1 binds to a [GC]AAA[GC] consensus sequence. MAP kinase 1 represses the expression of interferon gamma-induced genes. MAPK1 is activated by phosphorylation on Thr-185 and Tyr-187 in response to insulin and NGF. Both phosphorylations are required for activity. This antibody binds to the diphosphorylated form.

Alternate Names: Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, MAPK1, ERK2, PRKM1, PRKM2

Application Notes: E: 1:1,000-1:10,000; WB: 0.25-5 ug/ml; IHC: 0.4-1 ug/ml; ICC: 0.4-1 ug/ml

Accession No.: P28482

Antigen: Recombinant diphosphorylated human MAPK1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.2% BSA with 0.09% sodium azide. Antibody was purified by goat anti-mouse IgG affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.