MAPK10 polyclonal, anti-human, mouse

Background:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.

Synonyms: JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK

Cellular Location: Cytoplasm Lipid-anchor Membrane Mitochondrion Nucleus

Immunogen:
Recombinant protein of human MAPK10

Gene Symbol: MAPK10

Gene ID: 5602

Swiss prot: P53779

Calculated MW: 53kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.