MAPK14 Antibody (Center T180/Y182) Blocking peptide
€363.00
In stock
SKU
AC-BP12488c
Background:
The protein encoded by this gene is a member of the MAPkinase family. MAP kinases act as an integration point for multiplebiochemical signals, and are involved in a wide variety of cellularprocesses such as proliferation, differentiation, transcriptionregulation and development. This kinase is activated by variousenvironmental stresses and proinflammatory cytokines. Theactivation requires its phosphorylation by MAP kinase kinases(MKKs), or its autophosphorylation triggered by the interaction ofMAP3K7IP1/TAB1 protein with this kinase. The substrates of thiskinase include transcription regulator ATF2, MEF2C, and MAX, cellcycle regulator CDC25B, and tumor suppressor p53, which suggest theroles of this kinase in stress related transcription and cell cycleregulation, as well as in genotoxic stress response. Fouralternatively spliced transcript variants of this gene encodingdistinct isoforms have been reported.
Other Names:
Mitogen-activated protein kinase 14, MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Stress-activated protein kinase 2a, SAPK2a, MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
Gene Name: MAPK14 (HGNC:6876)
Gene ID: 1432
Primary Accession: Q16539
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is a member of the MAPkinase family. MAP kinases act as an integration point for multiplebiochemical signals, and are involved in a wide variety of cellularprocesses such as proliferation, differentiation, transcriptionregulation and development. This kinase is activated by variousenvironmental stresses and proinflammatory cytokines. Theactivation requires its phosphorylation by MAP kinase kinases(MKKs), or its autophosphorylation triggered by the interaction ofMAP3K7IP1/TAB1 protein with this kinase. The substrates of thiskinase include transcription regulator ATF2, MEF2C, and MAX, cellcycle regulator CDC25B, and tumor suppressor p53, which suggest theroles of this kinase in stress related transcription and cell cycleregulation, as well as in genotoxic stress response. Fouralternatively spliced transcript variants of this gene encodingdistinct isoforms have been reported.
Other Names:
Mitogen-activated protein kinase 14, MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Stress-activated protein kinase 2a, SAPK2a, MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
Gene Name: MAPK14 (HGNC:6876)
Gene ID: 1432
Primary Accession: Q16539
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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