MAPK7 Polyclonal Antibody

Background:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.

Research Area: Cancer, Neuroscience, Signal Transduction

Synonyms:
MAPK7, BMK1, ERK4, ERK5, PRKM7

Immunogen: Recombinant fusion protein of human MAPK7 (NP_002740.2).

Swissprot: Q13164
Gene ID: 5598

Calculated MW: 50 kDa/59 kDa/73 kDa/88 kDa
Observed MW: 50 kDa/80 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.