MAPK8IP3 Polyclonal Antibody

Background:
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. MAPK8IP3 (Mitogen-Activated Protein Kinase 8 Interacting Protein 3) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Arf6 trafficking events. GO annotations related to this gene include kinesin binding and receptor signaling complex scaffold activity. An important paralog of this gene is SPAG9.

Research Area: Signal Transduction

Synonyms:
C-jun-amino-terminal kinase-interacting protein 3, FLJ00027, Homolog of Drosophila Sunday driver 2, JIP-3, JIP3, JIP3, JNK / Stress Activated Protein Kinase Associated Protein 1, JNK Interacting Protein 3, JNK MAP kinase scaffold protein 3, JNK-interacting protein 3, JNK/SAPK associated protein 1, JSAP1, KIAA1066, MAPK8IP3, Mitogen Activated Protein kinase 8 Interacting Protein 3, Mitogen-activated protein kinase 8-interacting protein 3, Syd, SYD2

Immunogen: Synthetic peptide of human MAPK8IP3

Swissprot: Q9UPT6
Gene Accession: NP055948

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.26 mg/mL
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.