MAPKAP Kinase 2 polyclonal, anti-human, mouse

Background:
The MAPKAP kinases (for MAP kinase activated protein kinases) are a group of MAP kinase substrates which are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identifed and serve as substrates for the ERK and p38 MAP kinases. These include the serine/threonine kinases Rsk-1 (also designated MAPKAP kinase-1), Rsk-2 and Rsk-3, which are phosphorylated by ERK1 and ERK2. Similarly, p38 phosphorylates and activates the serine/threonine kinases MAPKAP kinase-2 and MAPKAP kinase-3 (also designated 3pK). The serine/threonine kinases Mnk1 and Mnk2 are substrates for both ERK and p38 MAP kinases.

Alternative Name:
MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAP-K2, MAPKAPK-2, MK-2, MK2, MAPKAPK2, MAP kinase activated protein Kinase 2, MAP kinase-activated protein kinase 2, MAPK activated protein kinase 2, MAPK-activated protein kinase 2, MAPK2, MAPKAP K2, MAPKAP kinase 2, MAPKAPK 2, MAPKAPK-2, MAPKAPK2, Mitogen activated protein kinase activated protein kinase 2, MK 2, MK2,

Application Dilution:
WB:1:500-1:1,000
IP:1:10-1:50

Specificity: MAPKAP Kinase 2 polyclonal antibody detects endogenous levels of MAPKAP Kinase 2 protein.

Immunogen:
Recombinant protein

MW: 46 kDa

Swiss-Prot: P49137(Human) P49138(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.