MAPKAPK-2 (N266) polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS3766
Background:
MAP kinase activated protein kinase 2 (MAPKAP Kinase 2), also known as p45 hsp27 kinase, is a 45-54 kDa serine/threonine protein kinase that contains a proline rich sequence and two putative SH3 binding sites. MAPKAP Kinase 2 is activated in response to stress, IL1 and TNF, possibly catalyzed by p38/Hog dependent phosphorylation. One of the major substrates of MAPKAP Kinase 2 is hsp27, which stimulates actin polymerization in order to facilitate recovery from destruction of cytoskeleton during cellular stresses. MAPKAP2 is implicated in several disorders including ischemic brain injury and heart failure and has been shown to be important in regulating stress resistance and the production of TNF alpha.
Alternative Name:
MAPKAP Kinase 2, MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAPK-2, MK2, EC 2.7.11.1, MAPKAPK2
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: MAPKAPK-2 (N266) polyclonal antibody detects endogenous levels of MAPKAPK-2 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 250-300 of Human MAPKAPK-2.
MW: ~ 46 kDa
Swis Prot.: P49137
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
MAP kinase activated protein kinase 2 (MAPKAP Kinase 2), also known as p45 hsp27 kinase, is a 45-54 kDa serine/threonine protein kinase that contains a proline rich sequence and two putative SH3 binding sites. MAPKAP Kinase 2 is activated in response to stress, IL1 and TNF, possibly catalyzed by p38/Hog dependent phosphorylation. One of the major substrates of MAPKAP Kinase 2 is hsp27, which stimulates actin polymerization in order to facilitate recovery from destruction of cytoskeleton during cellular stresses. MAPKAP2 is implicated in several disorders including ischemic brain injury and heart failure and has been shown to be important in regulating stress resistance and the production of TNF alpha.
Alternative Name:
MAPKAP Kinase 2, MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAPK-2, MK2, EC 2.7.11.1, MAPKAPK2
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: MAPKAPK-2 (N266) polyclonal antibody detects endogenous levels of MAPKAPK-2 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 250-300 of Human MAPKAPK-2.
MW: ~ 46 kDa
Swis Prot.: P49137
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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