MARK4 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60699
Background:
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. The serine/threonine (Ser/Thr) protein kinases are a group of proteins that are intimately involved in this process. MARK4 (MAP/microtubule affinity-regulating kinase 4), also known as MARKL1 or KIAA1860, is a 752 amino acid protein that contains one UBA domain, one protein kinase domain and one kinase-associated domain and belongs to the Ser/Thr protein kinase family. Expressed ubiquitously as two alternatively spliced isoforms, one of which is brain-specific, MARK4 uses ATP to catalyze the phosphorylation of target proteins and is thought to be involved in cell growth. MARK4 is upregulated in hepatocellular carcinoma cells, suggesting a role for MARK4 in tumorigenesis.
Alternative Name:
MAP/microtubule affinity-regulating kinase 4, MAP/microtubule affinity-regulating kinase-like 1, MARK4, KIAA1860, MARKL1
Application Dilution: WB: 1:500~1:1000
Specificity: MARK4 polyclonal antibody detects endogenous levels of MARK4 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human MARK4
MW: ~ 70 kDa
Swis Prot.: Q96L34
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. The serine/threonine (Ser/Thr) protein kinases are a group of proteins that are intimately involved in this process. MARK4 (MAP/microtubule affinity-regulating kinase 4), also known as MARKL1 or KIAA1860, is a 752 amino acid protein that contains one UBA domain, one protein kinase domain and one kinase-associated domain and belongs to the Ser/Thr protein kinase family. Expressed ubiquitously as two alternatively spliced isoforms, one of which is brain-specific, MARK4 uses ATP to catalyze the phosphorylation of target proteins and is thought to be involved in cell growth. MARK4 is upregulated in hepatocellular carcinoma cells, suggesting a role for MARK4 in tumorigenesis.
Alternative Name:
MAP/microtubule affinity-regulating kinase 4, MAP/microtubule affinity-regulating kinase-like 1, MARK4, KIAA1860, MARKL1
Application Dilution: WB: 1:500~1:1000
Specificity: MARK4 polyclonal antibody detects endogenous levels of MARK4 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human MARK4
MW: ~ 70 kDa
Swis Prot.: Q96L34
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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