MASP1 Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP18135c
Background:
This gene encodes a serine protease that functions as acomponent of the lectin pathway of complement activation. Thecomplement pathway plays an essential role in the innate andadaptive immune response. The encoded protein is synthesized as azymogen and is activated when it complexes with the pathogenrecognition molecules of lectin pathway, the mannose-binding lectinand the ficolins. This protein is not directly involved incomplement activation but may play a role as an amplifier ofcomplement activation by cleaving complement C2 or by activatinganother complement serine protease, MASP-2. The encoded protein isalso able to cleave fibrinogen and factor XIII and may may beinvolved in coagulation. A splice variant of this gene which lacksthe serine protease domain functions as an inhibitor of thecomplement pathway. Alternate splicing results in multipletranscript variants.
Other Names:
Mannan-binding lectin serine protease 1, 3421-, Complement factor MASP-3, Complement-activating component of Ra-reactive factor, Mannose-binding lectin-associated serine protease 1, MASP-1, Mannose-binding protein-associated serine protease, Ra-reactive factor serine protease p100, RaRF, Serine protease 5, Mannan-binding lectin serine protease 1 heavy chain, Mannan-binding lectin serine protease 1 light chain, MASP1, CRARF, CRARF1, PRSS5
Gene Name: MASP1
Gene ID: 5648
Primary Accession: P48740
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a serine protease that functions as acomponent of the lectin pathway of complement activation. Thecomplement pathway plays an essential role in the innate andadaptive immune response. The encoded protein is synthesized as azymogen and is activated when it complexes with the pathogenrecognition molecules of lectin pathway, the mannose-binding lectinand the ficolins. This protein is not directly involved incomplement activation but may play a role as an amplifier ofcomplement activation by cleaving complement C2 or by activatinganother complement serine protease, MASP-2. The encoded protein isalso able to cleave fibrinogen and factor XIII and may may beinvolved in coagulation. A splice variant of this gene which lacksthe serine protease domain functions as an inhibitor of thecomplement pathway. Alternate splicing results in multipletranscript variants.
Other Names:
Mannan-binding lectin serine protease 1, 3421-, Complement factor MASP-3, Complement-activating component of Ra-reactive factor, Mannose-binding lectin-associated serine protease 1, MASP-1, Mannose-binding protein-associated serine protease, Ra-reactive factor serine protease p100, RaRF, Serine protease 5, Mannan-binding lectin serine protease 1 heavy chain, Mannan-binding lectin serine protease 1 light chain, MASP1, CRARF, CRARF1, PRSS5
Gene Name: MASP1
Gene ID: 5648
Primary Accession: P48740
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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