Mast Cell Tryptase monoclonal, anti-human, mouse, rat

Description: Anti-Mast Cell Tryptase Rabbit Monoclonal Antibody . Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.

Protein Function:
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315)..

Other Names: Tryptase alpha/beta-1, Tryptase-1, 3.4.21.59, Tryptase I, Tryptase alpha-1, TPSAB1, TPS1, TPS2, TPSB1

Clone Name(s):
Clone: FHH-20

Subcellular Localization: Secreted. Released from the secretory granules upon mast cell activation..

Tissue Specificity: Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level)..

Gene ID: 7177

Immunogen: A synthesized peptide derived from human Mast Cell Tryptase

Calculated MW: 30515

Purification: Affinity-chromatography

Format: Liquid

Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.