MAT1A polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8325
Background:
Methionine adenosyltransferase (MAT) catalyzes the formation of S-adenosyltransferase (AdoMet) for methionine catabolism in the liver. Two different genes, MAT1A and MAT2A, encode a liver specific and non-liver specific form of MAT, designated MAT Iα and MAT IIα, respectively. Inactivation of the liver specific gene product, designated MAT I/III, associates with liver diseases such as cirrhosis. MAT Iα expression also correlates with a differentiated phenotype, whereas liver cells expressing MAT IIα present a dedifferentiated phenotype and lowered AdoMet synthesis. Likewise, NF-kB and TNFα cause a switch from MAT Iα to MAT IIα expression in human hepatocellular carcinoma (HCC), which facilitates cancer cell growth.
Alternative Name:
S-adenosylmethionine synthase isoform type-1, AdoMet synthase 1, Methionine adenosyltransferase 1, MAT 1, Methionine adenosyltransferase I/III, MAT-I/III, MAT1A, AMS1, MATA1
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: MAT1A polyclonal antibody detects endogenous levels of MAT1A protein.
Immunogen:
Recombinant full length Human MAT1A.
MW: ~ 44 kDa
Swis Prot.: Q00266
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Methionine adenosyltransferase (MAT) catalyzes the formation of S-adenosyltransferase (AdoMet) for methionine catabolism in the liver. Two different genes, MAT1A and MAT2A, encode a liver specific and non-liver specific form of MAT, designated MAT Iα and MAT IIα, respectively. Inactivation of the liver specific gene product, designated MAT I/III, associates with liver diseases such as cirrhosis. MAT Iα expression also correlates with a differentiated phenotype, whereas liver cells expressing MAT IIα present a dedifferentiated phenotype and lowered AdoMet synthesis. Likewise, NF-kB and TNFα cause a switch from MAT Iα to MAT IIα expression in human hepatocellular carcinoma (HCC), which facilitates cancer cell growth.
Alternative Name:
S-adenosylmethionine synthase isoform type-1, AdoMet synthase 1, Methionine adenosyltransferase 1, MAT 1, Methionine adenosyltransferase I/III, MAT-I/III, MAT1A, AMS1, MATA1
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: MAT1A polyclonal antibody detects endogenous levels of MAT1A protein.
Immunogen:
Recombinant full length Human MAT1A.
MW: ~ 44 kDa
Swis Prot.: Q00266
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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