MATK polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8326
Background:
All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine, Y527 in the case of Src p60, which is highly phosphorylated in the inactive form of the enzyme, while phosphorylated to a much lesser extent when the enzyme is active. For instance, a mutant of c-Src, in which Y527 is replaced by phenylalanine, is transforming and displays 5 to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as the carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also down regulates Fyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites. A Csk-like protein-tyrosine kinase of mouse cell origin (Ctk), also designated Ntk, and its human homolog, Lsk, have also been described.
Alternative Name:
Megakaryocyte-associated tyrosine-protein kinase, CSK homologous kinase, CHK, Hematopoietic consensus tyrosine-lacking kinase, Protein kinase HYL, Tyrosine-protein kinase CTK, MATK, CTK, HYL
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: MATK polyclonal antibody detects endogenous levels of MATK protein.
Immunogen:
Recombinant full length Human MATK.
MW: ~ 56 kDa
Swis Prot.: P42679
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine, Y527 in the case of Src p60, which is highly phosphorylated in the inactive form of the enzyme, while phosphorylated to a much lesser extent when the enzyme is active. For instance, a mutant of c-Src, in which Y527 is replaced by phenylalanine, is transforming and displays 5 to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as the carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also down regulates Fyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites. A Csk-like protein-tyrosine kinase of mouse cell origin (Ctk), also designated Ntk, and its human homolog, Lsk, have also been described.
Alternative Name:
Megakaryocyte-associated tyrosine-protein kinase, CSK homologous kinase, CHK, Hematopoietic consensus tyrosine-lacking kinase, Protein kinase HYL, Tyrosine-protein kinase CTK, MATK, CTK, HYL
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: MATK polyclonal antibody detects endogenous levels of MATK protein.
Immunogen:
Recombinant full length Human MATK.
MW: ~ 56 kDa
Swis Prot.: P42679
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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