Matrin 3 polyclonal, anti-human, mouse, rat

Background:
Matrin-3 is a nuclear matrix protein containing one matrin-type zinc finger and two RRM (RNA recognition motif) domains. Matrin-3 plays a role in transcription and may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the PSF-p54/NRB heteromer, Matrin-3 may play a role in the nuclear retention of defective RNAs. As the main substrate for PKA-mediated phosphorylation, Matrin-3 may serve as a rapid way of transferring information from synapses containing NMDA receptors to neuronal nuclei under physiological conditions. Also, the phosphorylation of Matrin-3 may contribute to neuronal death under pathological conditions. It is likely that Matrin-3 activity is regulated by calcium dependent interaction with CaM I and also by caspase induced cleavage.

Alternative Name:
MATR3, ALS21, KIAA0723, Matr3, MATR3, Matrin-3, Matrin3, MPD2, VCPDM, Vocal cord and pharyngeal weakness with distal myopathy,

Application Dilution:
WB:1:1,000-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: Matrin 3 polyclonal antibody detects endogenous levels of Matrin 3 protein.

Immunogen:
Recombinant protein

MW: 95 kDa

Swiss-Prot: P43243(Human) Q8K310(Mouse) P43244(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.