MAVS polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7844
Background:
MAVS (mitochondrial antiviral-signaling protein), also known as IPS1, KIAA1271, VISA or CARDIF, is a 540 amino acid protein that contains one CARD domain and several transmembrane domains, and localizes to the outer mitochondrial membrane. Expressed throughout the body with highest ex-pression in liver, heart, placenta, skeletal muscle and peripheral blood leuk-ocytes, MAVS functions downstream of proteins, such as RIG-I, that detect double-stranded (ds) viral replication and is required for proper immune re-sponse against ds viral infection. MAVS is thought to activate pathways that lead to the induction of antiviral cytokines and may protect the cells from viral-induced apoptosis. MAVS function can be inactivated via cleavage by a protease complex that degrades the CARD and transmembrane domains, thereby preventing MAVS from interacting with other proteins. Three isoforms of MAVS are expressed due to alternative splicing events.
Alternative Name:
CARD adapter inducing interferon beta, Cardif, DKFZp666M015, FLJ27482, FLJ41962, Interferon beta promoter stimulator protein 1, Interferon-beta promoter stimulatorprotein 1, Ips 1, IPS-1, Ips1, KIAA1271, MAVS, MAVS_HUMAN, Mitochondrial anti viral signaling protein, Mitochondrial Antiviral Signaling, Mitochondrial antiviral signaling protein, Mitochondrial antiviral-signaling protein, Putative NF kappa B activating protein 031N, Putative NF-kappa-B-activating protein 031N, Virus induced signaling adapter, Virus-induced-signaling adapter, VISA,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: MAVS polyclonal antibody detects endogenous levels of MAVS protein.
Immunogen:
Recombinant full length Human MAVS.
MW: ~ 57, 75 kDa
Swis Prot.: Q7Z434
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
MAVS (mitochondrial antiviral-signaling protein), also known as IPS1, KIAA1271, VISA or CARDIF, is a 540 amino acid protein that contains one CARD domain and several transmembrane domains, and localizes to the outer mitochondrial membrane. Expressed throughout the body with highest ex-pression in liver, heart, placenta, skeletal muscle and peripheral blood leuk-ocytes, MAVS functions downstream of proteins, such as RIG-I, that detect double-stranded (ds) viral replication and is required for proper immune re-sponse against ds viral infection. MAVS is thought to activate pathways that lead to the induction of antiviral cytokines and may protect the cells from viral-induced apoptosis. MAVS function can be inactivated via cleavage by a protease complex that degrades the CARD and transmembrane domains, thereby preventing MAVS from interacting with other proteins. Three isoforms of MAVS are expressed due to alternative splicing events.
Alternative Name:
CARD adapter inducing interferon beta, Cardif, DKFZp666M015, FLJ27482, FLJ41962, Interferon beta promoter stimulator protein 1, Interferon-beta promoter stimulatorprotein 1, Ips 1, IPS-1, Ips1, KIAA1271, MAVS, MAVS_HUMAN, Mitochondrial anti viral signaling protein, Mitochondrial Antiviral Signaling, Mitochondrial antiviral signaling protein, Mitochondrial antiviral-signaling protein, Putative NF kappa B activating protein 031N, Putative NF-kappa-B-activating protein 031N, Virus induced signaling adapter, Virus-induced-signaling adapter, VISA,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: MAVS polyclonal antibody detects endogenous levels of MAVS protein.
Immunogen:
Recombinant full length Human MAVS.
MW: ~ 57, 75 kDa
Swis Prot.: Q7Z434
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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