MBD1 antibody (clone 2C7), anti-human
€435.00
In stock
SKU
AC-AT2811a
Catalog Number: AC-AT2811a
Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, IHC, E
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Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, IHC, E
Request Information AC-AT2811a">Request Information
Background:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21.
Other Names:
Methyl-CpG-binding domain protein 1, CXXC-type zinc finger protein 3, Methyl-CpG-binding protein MBD1, Protein containing methyl-CpG-binding domain 1, MBD1, CXXC3, PCM1
Antigen Type:
Recombinant Protein
Gene Name: MBD1 (HGNC:6916)
Gene ID: 4152
NCBI Accession: NP_001191065.1;NP_001191066.1;NP_001191067.1;NP_001191068.1;NP_001191069.1;NP_001191070.1;NP_001191071.1;NP_001191072.1;NP_001191080.1;NP_002375.1;NP_056669.2;NP_056670.2;NP_056671.2;NP_056723.2
Primary Accession: Q9UIS9
Other Accession: NM_015846
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21.
Other Names:
Methyl-CpG-binding domain protein 1, CXXC-type zinc finger protein 3, Methyl-CpG-binding protein MBD1, Protein containing methyl-CpG-binding domain 1, MBD1, CXXC3, PCM1
Antigen Type:
Recombinant Protein
Gene Name: MBD1 (HGNC:6916)
Gene ID: 4152
NCBI Accession: NP_001191065.1;NP_001191066.1;NP_001191067.1;NP_001191068.1;NP_001191069.1;NP_001191070.1;NP_001191071.1;NP_001191072.1;NP_001191080.1;NP_002375.1;NP_056669.2;NP_056670.2;NP_056671.2;NP_056723.2
Primary Accession: Q9UIS9
Other Accession: NM_015846
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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