MBD1 polyclonal, anti- antibody
€285.00
In stock
SKU
AC-ABV11363-25
Catalog Number: AC-ABV11363-25
Size: 25 µg
Host: Rabbit IgG
Applications: WB, E
Datasheet
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Size: 25 µg
Host: Rabbit IgG
Applications: WB, E
Datasheet
Request Information
Background:
MBD1 is a transcriptional repressor that specifically binds to methylated CpG dinucleotides in promoter sequences. MBD1 acts by recruiting a variety of histone deacetylases (HDAC’s) and chromatin remodelling factors. MBD1-dependent transcriptional repression is mediated by ATF7IP through the recruitment of factors such as the histone methyltransferase SETDB1. MBD1 probably forms a complex with SETDB1 and ATF7IP which couples DNA methylation to H3K9 trimethylation and represses transcription.
Other Names:
CXXC3, PCM1, RFT, Methyl-CpG-Binding Domain 1
Primary Accession: Q9UIS9
Gene Name: MBD1 (HGNC:6916)
Gene ID: 4152
MBD1 is a transcriptional repressor that specifically binds to methylated CpG dinucleotides in promoter sequences. MBD1 acts by recruiting a variety of histone deacetylases (HDAC’s) and chromatin remodelling factors. MBD1-dependent transcriptional repression is mediated by ATF7IP through the recruitment of factors such as the histone methyltransferase SETDB1. MBD1 probably forms a complex with SETDB1 and ATF7IP which couples DNA methylation to H3K9 trimethylation and represses transcription.
Other Names:
CXXC3, PCM1, RFT, Methyl-CpG-Binding Domain 1
Primary Accession: Q9UIS9
Gene Name: MBD1 (HGNC:6916)
Gene ID: 4152
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