MBD2 polyclonal, anti-human

Quantity: 100 µg

Background:
Methyl-CpG-binding domain protein 2 is a protein that in humans is encoded by the MBD2 gene. It is mapped to 18q21.2. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG-binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.

Description:
Rabbit IgG polyclonal antibody for Methyl-CpG-binding domain protein 2 (MBD2) detection. Tested with WB in Human.

Synonyms:
DEMETHYLASE antibody, DKFZp586O0821 antibody, DMTase antibody, MBD 2 antibody, Mbd2 antibody, MBD2_HUMAN antibody, MBD2a antibody, Methyl CpG binding domain protein 2 antibody, Methyl CpG binding protein MBD2 antibody, Methyl-CpG-binding domain protein 2 antibody, Methyl-CpG-binding protein MBD2 antibody, NY CO 41 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human MBD2 recombinant protein (Position: W159-A411). Human MBD2 shares 98% amino acid (aa) sequence identity with mouse MBD2.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.