MBD3 polyclonal, anti-human

Background:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene.

Synonyms: MBD3

Cellular Location: Chromosome Nucleus

Immunogen:
Recombinant protein of human MBD3

Gene Symbol: MBD3

Gene ID: 53615

Swiss prot: O95983

Calculated MW: 33kDa

Recommended dilution:
WB 1:200-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.