MBD3 polyclonal antibody, anti-human, mouse

Background:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MBD3 belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). Methyl-CpG-binding domain protein 3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene.

Research Area: Epigenetics and Nuclear Signaling

Synonyms: MBD3, Methyl-CpG-binding domain protein 3, Methyl-CpG-binding protein MBD3

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year