MBD4 Antibody(Center) Blocking peptide
€363.00
In stock
SKU
AC-BP19391c
Background:
DNA methylation is the major modification of eukaryoticgenomes and plays an essential role in mammalian development. Humanproteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family ofnuclear proteins related by the presence in each of a methyl-CpGbinding domain (MBD). Each of these proteins, with the exception ofMBD3, is capable of binding specifically to methylated DNA. MBD4may function to mediate the biological consequences of themethylation signal. In addition, MBD4 has protein sequencesimilarity to bacterial DNA repair enzymes and thus may have somefunction in DNA repair. Further, MBD4 gene mutations are detectedin tumors with primary microsatellite-instability (MSI), a form ofgenomic instability associated with defective DNA mismatch repair,and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.
Other Names:
Methyl-CpG-binding domain protein 4, 322-, Methyl-CpG-binding endonuclease 1, Methyl-CpG-binding protein MBD4, Mismatch-specific DNA N-glycosylase, MBD4, MED1
Gene Name: MBD4 (HGNC:6919)
Gene ID: 8930
Primary Accession: O95243
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
DNA methylation is the major modification of eukaryoticgenomes and plays an essential role in mammalian development. Humanproteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family ofnuclear proteins related by the presence in each of a methyl-CpGbinding domain (MBD). Each of these proteins, with the exception ofMBD3, is capable of binding specifically to methylated DNA. MBD4may function to mediate the biological consequences of themethylation signal. In addition, MBD4 has protein sequencesimilarity to bacterial DNA repair enzymes and thus may have somefunction in DNA repair. Further, MBD4 gene mutations are detectedin tumors with primary microsatellite-instability (MSI), a form ofgenomic instability associated with defective DNA mismatch repair,and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.
Other Names:
Methyl-CpG-binding domain protein 4, 322-, Methyl-CpG-binding endonuclease 1, Methyl-CpG-binding protein MBD4, Mismatch-specific DNA N-glycosylase, MBD4, MED1
Gene Name: MBD4 (HGNC:6919)
Gene ID: 8930
Primary Accession: O95243
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
| Is Featured? | No |
|---|
Write Your Own Review