MBL2 polyclonal, anti-human, mouse, rat

Background:
Mannose-binding lectin protein C (MBL-C), also known as mannose-binding protein C; mannose-binding lectin 2, soluble (opsonic defect); mannan-binding lectin; mannan-binding protein; and soluble mannose-binding lectin, initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL-C is a key component in immune response due to its ability to directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. It binds to sugars on the surface of bacterial, fungal and parasitic cells through C-terminal, Ca2+-dependent carbohydrate-recognition domains. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, two types of MBL-associated serine proteases (MASP-1 and MASP-2) and a truncated form of MASP-2, designated small MBL-associated protein (sMAP) or MAp19, complex with MBL to activate the lectin pathway of the complement system. Activated MASPs subsequently cleave and activate downstream components of the complement pathway.

Alternative Name:
COLEC 1, COLEC1, Collectin-1, HSMBPC, Mannan binding lectin, Mannan binding protein, Mannan-binding protein, Mannose binding lectin (protein C) 2 soluble, Mannose binding lectin (protein C) 2, soluble (opsonic defect), Mannose binding lectin (protein C) 2, soluble, Mannose binding lectin 2 soluble, Mannose binding lectin 2, soluble (opsonic defect), Mannose binding lectin, Mannose binding lectin protein C2 soluble opsonic defect, Mannose binding protein, Mannose binding protein C, Mannose binding protein C precursor, Mannose-binding lectin, Mannose-binding protein C, MBL 2, MBL, MBL2, MBL2_HUMAN, MBL2D, MBP 1, MBP, MBP C, MBP-C, MBP1, MBPB, MBPC, MGC116832, MGC116833, Opsonic defect, protein C, Soluble mannose binding lectin,

Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200

Specificity: MBL2 polyclonal antibody detects endogenous levels of MBL2 protein.

Immunogen:
Recombinant full length Human MBL2.

MW: ~ 26 kDa

Swis Prot.: P11226

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.