MBNL1 Polyclonal Antibody

Background:
This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
MBNL1, EXP, MBNL

Immunogen: Recombinant fusion protein of human MBNL1 (NP_066368.2).

Swissprot: Q9NR56
Gene ID: 4154

Calculated MW: 33 kDa/34 kDa/36 kDa/37 kDa/39 kDa/40 kDa/41 kDa
Observed MW: 42 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.