MBP polyclonal, anti-human

Background:
Myelin basic protein (MBP) is the major extrinsic membrane protein of central nervous system myelin. MBP phosphorylation at Threonine 125 is a complex regulatory process that modulates the contribution of MBP to the stability of the myelin sheath. Mitogen-activated protein kinases modulate MBP phosphorylation during myelinogenesis and in the demyelinating disease multiple sclerosis. MBP phosphorylation is regulated by high-frequency stimulation but not low-frequency stimulation of the alveus, the myelinated output fibers of the hippocampus. It is proposed that during periods of increased neuronal activity, calcium activates axonal nitric oxide synthase, which generates the intercellular messengers nitric oxide and superoxide and regulates the phosphorylation state of MBP by MAPK.

Alternative Name:
MBP, GDB, Golli MBP, Golli MBP, myelin basic protein, Hemopoietic MBP, HMBPR, HUGO, MBP, MBP_CAVPO, MBP, MGC99675, MLD, Myelin A1 protein, Myelin A1 Protein, basic, Myelin basic protein, Myelin Deficient, Myelin membrane encephalitogenic protein, OTTHUMP00000163776, OTTHUMP00000174387, OTTHUMP00000174388, SHI, Shiverer, SP,

Application Dilution:
WB:1:1,000
IHC:1:50-1:200

Specificity: MBP polyclonal antibody detects endogenous levels of MBP protein.

Immunogen:
recombinant protein

MW: 33/21/19 kDa

Swiss-Prot: P02686(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.