MBTPS2 Polyclonal Antibody

Background:
This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.

Research Area: Cell Biology, Cardiovascular, Metabolism, Signal transduction

Synonyms:
BRESEK, Endopeptidase S2P, IFAP, KFSDX, MBTP2, MBTPS2, Membrane bound transcription factor site 2 protease, membrane-bound transcription factor peptidase, site 2, membrane-bound transcription factor protease, site 2, Membrane-bound transcription factor site-2 protease, S2P, S2P endopeptidase, Site 2 protease, SREBPs intramembrane protease, Sterol regulatory element-binding proteins intramembrane protease

Immunogen: Synthetic peptide of human MBTPS2

Swissprot: O43462
Gene Accession: NP056968

Calculated MW: 57 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:10-1:50, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.