MC1R Polyclonal Antibody

Background:
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

Research Area: Metabolism, Neuroscience

Synonyms:
CMM5, MC1-R, MC1R, Melanocortin 1 receptor, Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor), Melanocortin receptor 1, Melanocyte-stimulating hormone receptor, Melanotropin receptor, MSH-R, MSHR, MSHR, SHEP2

Immunogen: Synthetic peptide of human MC1R

Swissprot: Q01726
Gene Accession: NP_002377

Calculated MW: 35 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-6875/sc-9899/sc-28990