MCAM polyclonal, anti-human

Background:
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Synonyms: CD146, MUC18, HEMCAM, METCAM, MelCAM

Cellular Location: Membrane

Immunogen:
A synthetic peptide of human MCAM

Gene Symbol: MCAM

Gene ID: 4162

Swiss prot: P43121

Calculated MW: 72kDa

Recommended dilution:
WB 1:500-2000, IHC 1:40-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.