MCAM polyclonal (C-term), anti-human
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In stock
SKU
AC-AP2767b
Catalog Number: AC-AP2767b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB20607
Applications: WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB20607
Applications: WB, IHC-P
Datasheet
Request Information
Background:
MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. It could be an adhesion molecule active in neural crest cells during embryonic development. It acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
Other Names:
Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12, Melanoma cell adhesion molecule, Melanoma-associated antigen A32, Melanoma-associated antigen MUC18, S-endo 1 endothelial-associated antigen, CD146, MCAM, MUC18
Target/Specificity:
This MCAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 532-558 amino acids from the C-terminal region of human MCAM.
Antigen Region:
532-558
Antigen Type: Synthetic Peptide
Gene Name: MCAM
Gene ID: 4162
Primary Accession: P43121
NCBI Accession: NP_006491.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. It could be an adhesion molecule active in neural crest cells during embryonic development. It acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
Other Names:
Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12, Melanoma cell adhesion molecule, Melanoma-associated antigen A32, Melanoma-associated antigen MUC18, S-endo 1 endothelial-associated antigen, CD146, MCAM, MUC18
Target/Specificity:
This MCAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 532-558 amino acids from the C-terminal region of human MCAM.
Antigen Region:
532-558
Antigen Type: Synthetic Peptide
Gene Name: MCAM
Gene ID: 4162
Primary Accession: P43121
NCBI Accession: NP_006491.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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