MCM10 Polyclonal Antibody

Background:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

Research Area: Epigenetics and Nuclear Signaling

Synonyms:
Minichromosome Maintenance 10 Replication Initiation Factor, Minichromosome Maintenance Complex Component 10, Protein MCM10 Homolog, HsMCM10, MCM10 Minichromosome Maintenance Deficient 10 , Homolog Of Yeast MCM10, PRO2249, CNA43, DNA43

Immunogen: Fusion protein of human MCM10

Swissprot: Q7L590
Gene Accession: BC009108

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.