MCM2 / BM28 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6107
Background:
The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATPbinding motif, which is predicted to mediate ATP-dependent opening of doublestranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the ostreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro.
Alternative Name:
DNA replication licensing factor MCM2, Minichromosome maintenance protein 2 homolog Nuclear protein BM28, MCM2, BM28, CCNL1, CDCL1, KIAA0030
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: MCM2 polyclonal antibody detects endogenous levels of MCM2 protein.
Immunogen:
Recombinant full length Human MCM2.
MW: ~ 102 kDa
Swis Prot.: P49736
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATPbinding motif, which is predicted to mediate ATP-dependent opening of doublestranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the ostreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro.
Alternative Name:
DNA replication licensing factor MCM2, Minichromosome maintenance protein 2 homolog Nuclear protein BM28, MCM2, BM28, CCNL1, CDCL1, KIAA0030
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: MCM2 polyclonal antibody detects endogenous levels of MCM2 protein.
Immunogen:
Recombinant full length Human MCM2.
MW: ~ 102 kDa
Swis Prot.: P49736
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
| Is Featured? | No |
|---|
Write Your Own Review