MCM2 (Phospho-Ser139) Rabbit polyclonal antibody, anti-human, mouse, rat

Background:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4| 6| and 7| and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated| and thus regulated by| protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found| but the full-length nature of some variants has not been defined.

Research Area: Epigenetics and nuclear signaling

Synonyms: MCM2 , Ser139 , DNA replication licensing factor MCM2, EC 3.6.4.12, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year