MCM2 Polyclonal Antibody

Background:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
MCM2, BM28, CCNL1, CDCL1, D3S3194, DFNA70, MITOTIN, cdc19

Immunogen: Recombinant fusion protein of human MCM2 (NP_004517.2).

Swissprot: P49736
Gene ID: 4171

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IHC 1:100-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.