MCM3 antibody (clone 30), anti-human
€435.00
In stock
SKU
AC-AT2820a
Catalog Number: AC-AT2820a
Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, IF, E
Request Information AC-AT2820a">Request Information
Background:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.
Other Names:
DNA replication licensing factor MCM3, DNA polymerase alpha holoenzyme-associated protein P1, P1-MCM3, RLF subunit beta, p102, MCM3
Antigen Type:
Recombinant Protein
Gene Name: MCM3 (HGNC:6945)
Gene ID: 4172
NCBI Accession: NP_001257401.1;NP_002379.3
Primary Accession: P25205
Other Accession: NM_002388
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.
Other Names:
DNA replication licensing factor MCM3, DNA polymerase alpha holoenzyme-associated protein P1, P1-MCM3, RLF subunit beta, p102, MCM3
Antigen Type:
Recombinant Protein
Gene Name: MCM3 (HGNC:6945)
Gene ID: 4172
NCBI Accession: NP_001257401.1;NP_002379.3
Primary Accession: P25205
Other Accession: NM_002388
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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