MCM3 Polyclonal Antibody

Background:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly witHuman, MouseCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
Cervical cancer proto oncogene 5, DNA polymerase alpha holoenzyme associated P1, DNA polymerase alpha holoenzyme associated protein P1, DNA polymerase alpha holoenzyme-associated protein P1, DNA replication factor MCM3, DNA replication licensing factor mcm3, HCC 5, HCC5, hRlf beta subunit, Human cervical cancer proto oncogene 5, MCM 3, mcm3, MCM3 minichromosome maintenance deficient 3, MCM3, MGC1157, Minichromosome maintenance complex component 3, Minichromosome maintenance deficient 3, Minichromosome maintenance protein 3, P1 h, P1 MCM3, P1 Protein, P1-MCM3, P1.h, p102, P102 protein, Replication licensing factor beta subunit, RLF beta subunit, RLF subunit beta, RLFB

Immunogen: Recombinant protein of human MCM3

Swissprot: P25205
Gene Accession: BC001626

Calculated MW: 91 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.2 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-9849/sc-9850