MCM3AP Polyclonal Antibody

Background:
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability.

Research Area: Cell Biology, Epigenetics and Nuclear Signaling

Synonyms:
80 kDa MCM3 associated protein, 80 kDa MCM3-associated protein, FLJ44336, FLJ45306, Germinal center associated nuclear protein, KIAA0572, MAP80, MCM3 import protein, MCM3 minichromosome maintenance deficient 3 associated protein, MCM3A, MCM3A, Mcm3ap, Minichromosome maintenance complex component 3 associated protein, Minichromosome maintenance deficient 3 associated protein, Minichromosome maintenance protein 3 associated protein, Protein GANP, SAC3

Immunogen: Recombinant protein of human MCM3AP

Swissprot: O60318
Gene Accession: BC104958

Calculated MW: 218 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-83297/sc-83298