MCM4 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP14534b
Background:
The protein encoded by this gene is one of the highlyconserved mini-chromosome maintenance proteins (MCM) that areessential for the initiation of eukaryotic genome replication. Thehexameric protein complex formed by MCM proteins is a key componentof the pre-replication complex (pre_RC) and may be involved in theformation of replication forks and in the recruitment of other DNAreplication related proteins. The MCM complex consisting of thisprotein and MCM2, 6 and 7 proteins possesses DNA helicase activity,and may act as a DNA unwinding enzyme. The phosphorylation of thisprotein by CDC2 kinase reduces the DNA helicase activity andchromatin binding of the MCM complex. This gene is mapped to aregion on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, aDNA-activated protein kinase involved in the repair of DNAdouble-strand breaks. Alternatively spliced transcript variantsencoding the same protein have been reported.
Other Names:
DNA replication licensing factor MCM4, CDC21 homolog, P1-CDC21, MCM4, CDC21
Gene Name: MCM4 (HGNC:6947)
Gene ID: 4173
Primary Accession: P33991
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is one of the highlyconserved mini-chromosome maintenance proteins (MCM) that areessential for the initiation of eukaryotic genome replication. Thehexameric protein complex formed by MCM proteins is a key componentof the pre-replication complex (pre_RC) and may be involved in theformation of replication forks and in the recruitment of other DNAreplication related proteins. The MCM complex consisting of thisprotein and MCM2, 6 and 7 proteins possesses DNA helicase activity,and may act as a DNA unwinding enzyme. The phosphorylation of thisprotein by CDC2 kinase reduces the DNA helicase activity andchromatin binding of the MCM complex. This gene is mapped to aregion on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, aDNA-activated protein kinase involved in the repair of DNAdouble-strand breaks. Alternatively spliced transcript variantsencoding the same protein have been reported.
Other Names:
DNA replication licensing factor MCM4, CDC21 homolog, P1-CDC21, MCM4, CDC21
Gene Name: MCM4 (HGNC:6947)
Gene ID: 4173
Primary Accession: P33991
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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