MCM4 polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP14534B
Catalog Number: AC-AP14534B
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34423
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34423
Applications: IHC-P, WB
Datasheet
Request Information
Background:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
Other Names:
DNA replication licensing factor MCM4, CDC21 homolog, P1-CDC21, MCM4, CDC21
Target/Specificity:
This MCM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 637-665 amino acids from the C-terminal region of human MCM4.
Antigen Region:
637-665
Antigen Type: Synthetic Peptide
Gene Name: MCM4 (HGNC:6947)
Gene ID: 4173
Primary Accession: P33991
NCBI Accession: NP_005905.2;NP_877423.1
Other Accession: P49717; P30664; NP_005905.2; NP_877423.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
Other Names:
DNA replication licensing factor MCM4, CDC21 homolog, P1-CDC21, MCM4, CDC21
Target/Specificity:
This MCM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 637-665 amino acids from the C-terminal region of human MCM4.
Antigen Region:
637-665
Antigen Type: Synthetic Peptide
Gene Name: MCM4 (HGNC:6947)
Gene ID: 4173
Primary Accession: P33991
NCBI Accession: NP_005905.2;NP_877423.1
Other Accession: P49717; P30664; NP_005905.2; NP_877423.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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