MCM7 antibody (clone 6C2), anti-human
€435.00
In stock
SKU
AC-AT2821a
Catalog Number: AC-AT2821a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, IF, E
Request Information AC-AT2821a">Request Information
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, IF, E
Request Information AC-AT2821a">Request Information
Background:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Other Names:
DNA replication licensing factor MCM7, CDC47 homolog, P11-MCM3, MCM7, CDC47, MCM2
Antigen Type:
Recombinant Protein
Gene Name: MCM7 (HGNC:6950)
Gene ID: 4176
NCBI Accession: NP_001265524.1;NP_005907.3;NP_877577.1
Primary Accession: P33993
Other Accession: BC009398
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Other Names:
DNA replication licensing factor MCM7, CDC47 homolog, P11-MCM3, MCM7, CDC47, MCM2
Antigen Type:
Recombinant Protein
Gene Name: MCM7 (HGNC:6950)
Gene ID: 4176
NCBI Accession: NP_001265524.1;NP_005907.3;NP_877577.1
Primary Accession: P33993
Other Accession: BC009398
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
| Is Featured? | No |
|---|
Write Your Own Review